Week 1 NFL Betting Lines
It’s week 1 of the NFL season and the betting lines are out. Thursday Night Football has the defending Super Bowl champions in action against one of the betting favorites this season in the Detroit Lions. The 1pm slate features a few divisional matchups between the Bengals and Browns. Eight of the Browns’ last nine home openers have gone over the point total. Rookie QB Anthony Richardson will take on Trevor Lawrence and Jacksonville. The Colts have lost 7 straight in Week 1.
The afternoon features the Eagles off of a Super Bowl loss vs the Patriots at Gillette. Seven of the Patriots’ last eight season openers have gone under the point total. The new look Green Bay Packers play a divisional game vs Justin Field and the Bears. Each of the Bears’ last six home openers have gone under the point total. The Cowboys take on the Giants on Sunday night football. Each of the Giants’ last nine home openers have gone under the point total. And Aaron Rodgers makes his Jets debut against the AFC East Champion Buffalo Bills. Seven of the Bill’s last eight road games have gone under the total.
Underdogs have been very successful in Week 1 over the the past 10 years going 112-91-4 (55%) Since 2005, favorites of 6 or more points in NFL Week 1 are 39-51-2 (43%) ATS per @Bet_Labs
Updated NFL Week 1 Betting Lines/Spreads

KANSAS CITY, MISSOURI – JANUARY 30: Quarterback Patrick Mahomes #15 of the Kansas City Chiefs fires up the crowd after the team was introduced before in the AFC Championship Game at Arrowhead Stadium on January 30, 2022 in Kansas City, Missouri. (Photo by Jamie Squire/Getty Images)
Thursday Night Football 8:15pm
- KC -6.5 vs DET O/U 53.5

SANTA CLARA, CALIFORNIA – JANUARY 22: Brock Purdy #13 of the San Francisco 49ers looks to pass against the Dallas Cowboys during the first quarter in the NFC Divisional Playoff game at Levi’s Stadium on January 22, 2023 in Santa Clara, California. (Photo by Thearon W. Henderson/Getty Images)
Sunday 1:00pm Kickoff
- MIN -6 vs TB O/U 45.5
- PIT +2.5 vs SF O/U 41
- NO -3 vs TEN O/U 41
- BAL -10 vs HOU O/U 44
- IND +5 vs JAX O/U 45
- CLE +2.5 vs CIN O/U 47.5
- WAS -7 vs AZ O/U 38
- ATL -3.5 vs CAR O/U 39.5

PHILADELPHIA, PENNSYLVANIA – OCTOBER 02: Jalen Hurts #1 of the Philadelphia Eagles yells during pregame against the Jacksonville Jaguars at Lincoln Financial Field on October 02, 2022 in Philadelphia, Pennsylvania. (Photo by Mitchell Leff/Getty Images)
4:25pm kickoff
- NE +4 vs PHI O/U 45
- LAC -3 vs MIA O/U 51
- SEA -5.5 vs LAR O/U 46.5
- CHI -1 vs GB O/U 43
- DEN -4 vs LV O/U 44

NEW ORLEANS, LOUISIANA – DECEMBER 02: Dak Prescott #4 of the Dallas Cowboys celebrates during the second half against the New Orleans Saints at the Caesars Superdome on December 02, 2021 in New Orleans, Louisiana. (Photo by Jonathan Bachman/Getty Images)
SUNDAY NIGHT FOOTBALL 8:20PM
- NYG +3.5 vs DAL O/U 46.5

EAST RUTHERFORD, NEW JERSEY – AUGUST 26: Aaron Rodgers #8 of the New York Jets waits in the tunnel prior to a preseason game against the New York Giants at MetLife Stadium on August 26, 2023 in East Rutherford, New Jersey. (Photo by Mike Stobe/Getty Images)
MONDAY NIGHT FOOTBALL 8:15
- NYJ +2.5 vs BUF O/U