BOSTON - The Red Sox lost to the Giants 7-6 in 15 innings in a game that took nearly six hours to play.
50 players were used in total, including 24 pitchers, tying a major league record for the most pitchers to appear in a single game.
San Francisco's Alex Dickerson hit a sacrifice fly in the 15th inning off Boston pitcher Trevor Kelley.
The Giants took the lead in the top of the 13th on a Brandon Crawford RBI double, but the Red Sox tied the game in the bottom of the 13th when third-string catcher Juan Centeno worked a bases loaded walk.
The Sox trailed 5-1 after four innings, but tied the ballgame two innings later. Mitch Moreland and Christian Vazquez knocked RBI doubles as part of a three-run sixth inning to pull into a 5-5 tie.
Jackie Bradley Jr. drove in two and hit a solo homer.
Boston starter Nathan Eovaldi was hit hard, giving up five runs over four innings of work.
Carl Yastrzemski's grandson, Mike, was responsible for one of those runs, homering in the fourth.
A Yastrzemski just homered at Fenway.
Can you believe it? pic.twitter.com/IaEhCDyhwF
— MLB (@MLB) September 18, 2019
Yastrzemski went 2-for-7 on the night.
The series continues on Wednesday night. Boston will send Jhoulys Chacin to the mound against right hander Jeff Samardzija.