The hype surrounding pitcher Shohei Ohtani was over by the second inning.
The Angels' phenom departed after only 66 pitches, due to a blister on his right middle finger.
Ohtani gave up three runs on four hits in his two-inning outing, including the first of Mookie Betts' three home runs for the game.
The Angels bullpen didn't fare much better, allowing the third inning to open up home-run derby style.
Betts finished off the inning with his second home run of the game.
Home run production would continue, with a solo hit by Rafael Devers in the fourth followed by a third moon shot by Betts in the eighth.
The 10-1 win over Los Angeles allowed the Red Sox to improve to 14-2 on the season. They face the Angels again tonight in the second game of the West Coast swing.